Extremity Trauma & Regenerative Medicine
Extremity injuries are the most commonly injured part of the body and account for approximately two-thirds of the initial hospital costs, rehospitalizations, and reasons for medical retirement from active duty. Our research effort focuses on optimizing the outcomes of extremity injuries and burn. We achieve this by conducting research designed to reduce initial injury complications and use advanced regenerative medicine technologies to replace missing tissue such as bone, muscle, and skin.
- To return Wounded Warriors to full function after extremity injury and burn
- Define the clinical problems and barriers of Wounded Warriors from retrospective studies and trauma registries
- Provide critical information for developing Clinical Practice Guidelines
- Develop regenerative solutions for missing skin and musculoskeletal tissue
- Conduct prospective clinical trials to determine best practice
- Extremity Trauma
- Regenerative Medicine
- Clinical Trials
CURRENT PRECLINICAL RESEARCH EFFORTS
- Develop a biofilm dispersive graft that promotes bone healing while reducing infection
- Improve outcomes of volumetric muscle loss injuries by reducing fibrosis and regenerating missing skeletal muscle using tissue engineering and regenerative medicine approaches including: autologous minced muscle grafts, biological scaffolds, stem cells, and microvascular fragments
- Develop readily-available vascularized full thickness skin graft
- Elucidate mechanisms that cause deleterious effects on healing associated with polytrauma and open fractures
CURRENT CLINICAL RESEARCH EFFORTS
- Define the clinical issues to help develop research gap areas
- Determine impact of Return-to-Run Clinical Pathway on return to duty rates of those with severely injury lower extremities
- Participate and contribute patients in multi-center clinical trials (www.metrc.org)
Contact the ETRM Research Director, click here.
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Zamora DO, S Natesan, S Becerra, N Wrice, E Chung, LJ Suggs, RJ Christy. Enhanced wound vascularization using a dsASCs seeded FPEG scaffold. Angiogenesis. 2013 Oct;16(4):745-57.
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