U.S. ARMY INSTITUTE OF SURGICAL RESEARCH
"Optimizing Combat Casualty Care"

Coagulation & Blood Research (C&BR)


RESEARCH FOCUS

Develop products and approaches to resuscitate combat casualties. Combat injuries cause major bleeding that is often worsened by exhaustion of the blood’s normal ability to clot. Blood products are vital to treating severely injured casualties, but lose function during processing, storage and transportation. We focus on understanding these complex problems and on finding ways to deliver safe and effective blood products to the battlefield.


RESEARCH GOALS

To deliver novel approaches to blood product storage and treatment of coagulation disorders that:

  • Ensure an adequate supply of safe and effective blood products and cellular therapies to support the care of trauma patients in military operations around the globe
  • Enhance operational flexibility in remote and austere environments to support prolonged field care

CORE COMPETENCIES

  • Research Blood Bank
  • Coagulation and platelet analysis
  • Animal and Human Research and Model Development

CURRENT RESEARCH EFFORTS

  • Development of new ways to store platelets, the shortest-lived cellular components of blood that are critical to blood clotting
  • Development of dried blood plasma, which will permit resuscitation of wounded patients with vital coagulation proteins close to the point of injury where blood is usually unavailable
  • Development of blood pathogen reduction technologies
  • Development of battlefield blood collection and transfusion methods
  • Understanding changes in coagulation and platelet function in trauma patients
  • Develop cellular therapies to support resuscitation of critically injured patients and mitigate multiorgan failure
  • Support development of extracorporeal life support systems for use in trauma care by defining blood/device interactions and optimal anticoagulation protocols

PRODUCTS DELIVERED TO THE WARFIGHTER

  • • Freeze-dried plasma (universal blood type, pathogen-reduced)
  • • Improved protocols for whole blood collection, universal donor identification
  • • Clinical practice guidelines for the use of tranexamic acid, whole blood, and coagulation diagnostics (ROTEM)

Contact the Coagulation & Blood Research Director, click here.


RECENT PUBLICATIONS

James A. Bynum, M. Adam Meledeo, Todd M. Getz, Armando C. Rodriguez, James K. Aden, Andrew P. Cap, Heather F. Pidcoke. Bioenergetic Profiling of Platelet Mitochondria during Storage: 4°C Storage Extends Platelet Mitochondrial Function and Viability. Transfusion. Accepted for publication Jan 15, 2016.

Todd M. Getz, Robbie K. Montgomery, James A. Bynum, James K. Aden, Heather F. Pidcoke and Andrew P. Cap. Storage of platelets at 4°C in platelet additive solutions prevents aggregate formation and preserves platelet functional responses. Transfusion. Epub 8 Feb 2016.

Kristin M. Reddoch, Robbie K. Montgomery, Armando C. Rodriguez, M. Adam Meledeo, Heather F. Pidcoke, Anand K. Ramasubramanian, Andrew P. Cap. Endothelium-derived inhibitors efficiently attenuate the aggregation and adhesion responses of refrigerated platelets. Shock. Vol 45, Issue 2, February 2016, pages 220–227.

Andrew P. Cap. Platelet storage: a license to chill! Transfusion. Volume 56, Issue 1, Jan 2016. pages 13–16.

Xiaowu Wu, Daniel N Darlington, Andrew P Cap. Procoagulant and Fibrinolytic Activity after Polytrauma in Rat. American Journal of Physiology-Regulatory, Integrative and Comparative Physiology. December 2015 Vol. no. , DOI: 10.1152/ajpregu.00401.2015

Daniel N Darlington, Mary D Gonzales, Teresa Craig, Michael A Dubick, Andrew P Cap, Martin G Schwacha. Trauma-induced coagulopathy is associated with a complex inflammatory response in the rat. Shock. Vol 44, August 2015. Pages 129-137.

Heather F Pidcoke, Claire L Isbell, Maryanne C Herzig, Chriselda G Fedyk, Beverly S Schaffer, Kevin K Chung, Christopher E White, Steven E Wolf, Charles E Wade, Andrew P Cap. Acute blood loss during burn and soft tissue excisions: An observational study of blood product resuscitation practices and focused review. Journal of Trauma and Acute Care Surgery. Vol 78, Issue 6. June 2015. Pages S39-S47.

Nicolas J Prat, Robbie Montgomery, Andrew P Cap, Michael A Dubick, Jean-Claude Sarron, Casimir Destombe, Philippe May, Pascal Magnan. Comprehensive evaluation of coagulation in swine subjected to isolated primary blast injury. Shock. Vol 43, Issue 6, June 2015. Pages 598-603.

James Eric Campbell, James Keith Aden, Andrew Peter Cap. Acute traumatic coagulopathy: Whole blood thrombelastography measures the tip of the iceberg. Journal of Trauma and Acute Care Surgery. Vol 78, Issue 5, May 2015. Pages 955-961.

Pidcoke HF, McFaul SJ, Ramasubramanian AK, Parida BK, Mora AG, Fedyk CG, Valdez-Delgado KK, Montgomery RK, Reddoch KM, Rodriguez AC, Aden JK, Jones JA, Bryant RS, Scherer MR, Reddy HL, Goodrich RP, Cap AP. Primary hemostatic capacity of whole blood: a comprehensive analysis of pathogen reduction and refrigeration effects over time. Transfusion. 2013 Jan;53 Suppl 1:137S-149S. doi: 10.1111/trf.12048. PMID:23301966