U.S. ARMY INSTITUTE OF SURGICAL RESEARCH
"Optimizing Combat Casualty Care"

Sensory Trauma and Vision Restoration


RESEARCH FOCUS

Conduct advanced research to develop treatments, methods and modeling that protect, repair and restore the eye and vision from injuries sustained by our Warfighters in the defense of our nation. We aim to leverage collaborations with industry and other researchers to achieve these goals.


RESEARCH GOALS

Be our Nation's answer to the challenges faced in the detection and treatment of combat related eye and vision disorders.


CORE COMPETENCIES

  • Retinal Advanced Tissue Technologies
  • Translational Research
  • Ocular Blast Induced Trauma characterization
  • Biomaterials and drug delivery
  • Ocular Imaging
  • Laser Bioeffects

CURRENT RESEARCH EFFORTS

  • Use of Adult Stem Cells in the Development of cell based eye trauma therapy
  • Evaluating the ocular effects of blast
  • Supercritical CO2 processing of tissues for use as therapeutic platforms
  • Utilizing Cross-linked amniotic membrane to seal corneal lacerations
  • Developing advanced treatments for burn induced exposure keratopathy to include: cross-linked amniotic membrane, eye wound chamber development, scleral lens
  • Characterizing the inflammatory profile of severe ocular surface diseases
  • Evaluating extended release drugs platforms to treatment ocular surface disorders
  • Use of magnetic nanoparticles to deliver therapeutic cells to the eye

Contact the Sensory Trauma Research Director, click here.


RECENT PUBLICATIONS

Greene WA, Burke TA, Kaini RR, Por ED, Wang HC. Polarized Secretion of Matrix Metalloproteinases and Their Inhibitors by Retinal Pigment Epithelium Derived from Induced Pluripotent Stem Cells During Wound Healing. Journal of Ocular Pharmacology and Therapeutics. 2017 Apr 1;33(3):132-40.

McDaniel J, Johnson A, Zamora DO. AMNIOTIC MEMBRANE ALLOGRAFTS MAINTAIN KEY BIOLOGICAL PROPERTIES POST SCCO2 AND LYOPHILIZATION PROCESSING. Investigative Ophthalmology & Visual Science. 2017 Jun 23;58(8):133-.

Zhu Y, Morris R, Edsall P, Akers A, Elliott W, Lund B, Cleland J. Head acceleration induced by blast wave exposure leads to abnormal visual evoked potential and eletroretinography in rats. Investigative Ophthalmology & Visual Science. 2017 Jun 23;58(8):4893-.

Rios JD, Becera S, Babineaux J, Johnson P, Edsall P, Elliott W, Wienandt N, Brown AW, Lund B. Primary blast overpressure causes pathological changes on retina and optic nerve in a rat model. Investigative Ophthalmology & Visual Science. 2017 Jun 23;58(8):1758-.

Por ED, Sandoval ML, Thomas-Benson C, Burke TA, Brackley AD, Jeske NA, Cleland JM, Lund BJ. Repeat low-level blast exposure increases transient receptor potential vanilloid 1 (TRPV1) and endothelin-1 (ET-1) expression in the trigeminal ganglion. PloS one. 2017 Aug 10;12(8):e0182102.

Cornell LE, Wehmeyer JL, Johnson AJ, Desilva MN, Zamora DO. Magnetic Nanoparticles as a Potential Vehicle for Corneal Endothelium Repair. Military medicine. 2016 May;181(5S):232-9.

Cornell LE, Greene W, Haich RO, Mangum LC, Garcia GR, Guymon CH, Akers KS, Landry J, McDaniel J, Griffith G, Por E. Proceedings of the 4th Annual United States Army Institute of Surgical Research Summer Undergraduate Research Internship Program 2016. Journal of Translational Medicine. 2017 Feb 22;15(2):19.

Por ED, Greene WA, Burke TA, Wang HC. Trichostatin A inhibits retinal pigmented epithelium activation in an in vitro model of proliferative vitreoretinopathy. Journal of Ocular Pharmacology and Therapeutics. 2016 Sep 1;32(7):415-24.

Jones K, Choi JH, Sponsel WE, Gray W, Groth SL, Glickman RD, Lund BJ, Reilly MA. Low-Level Primary Blast Causes Acute Sensory Trauma in Rabbits. Journal of neurotrauma. 2016 Jul 1;33(13):1194-201.

Por ED, Choi JH, Lund BJ. Low-level blast exposure increases Transient Receptor Potential Vanilloid 1 (TRPV1) expression in the rat cornea. Current eye research. 2016 Oct 2;41(10):1294-301.