U.S. ARMY INSTITUTE OF SURGICAL RESEARCH
"Optimizing Combat Casualty Care"

Ocular Trauma and Vision Restoration


RESEARCH FOCUS

Conduct advanced research to develop treatments, methods and modeling that protect, repair and restore the eye and vision from injuries sustained by our Warfighters in the defense of our nation. We aim to leverage collaborations with industry and other researchers to achieve these goals.


RESEARCH GOALS

Be our Nation's answer to the challenges faced in the detection and treatment of combat related eye and vision disorders.


CORE COMPETENCIES

  • Retinal Advanced Tissue Technologies
  • Translational Research
  • Ocular Blast Induced Trauma characterization
  • Biomaterials and drug delivery
  • Ocular Imaging
  • Laser Bioeffects

CURRENT RESEARCH EFFORTS

  • Use of Adult Stem Cells in the Development of cell based eye trauma therapy
  • Evaluating the ocular effects of blast
  • Supercritical CO2 processing of tissues for use as therapeutic platforms
  • Utilizing Cross-linked amniotic membrane to seal corneal lacerations
  • Developing advanced treatments for burn induced exposure keratopathy to include: cross-linked amniotic membrane, eye wound chamber development, scleral lens
  • Characterizing the inflammatory profile of severe ocular surface diseases
  • Evaluating extended release drugs platforms to treatment ocular surface disorders
  • Use of magnetic nanoparticles to deliver therapeutic cells to the eye

Contact the Ocular Trauma Research Director, click here.


RECENT PUBLICATIONS

B.J. Lund, D.J. Lund and P.R. Edsall, Damage threshold from large retinal spot size repetitive-pulse laser exposures. submitted to Health Physics Journal (2013).

B.J. Lund and Karl Schulmeister, On the exposure limits for extended source multiple pulse laser exposures. Journal of Laser Applications 25(4), 042004-1-11 (2013).

Albert Muniz, Whitney A Green, Mark L Plamper, Jae Hyek Choi, Anthony J Johnson, Andrew T Tsin Heuy-Ching Wang. Retinoid Uptake, Processing and Secretion in Human iPS-RPE Support the Visual Cycle. Invest Ophthalmol Vis Sci, doi:iovs.13-11740 [pii] 10.1167/iovs.13-11740 (2013).

Zamora, DO, Natesan, S, Suggs, LJ, and Christy, R. Enhanced Wound Vascularization Using a dsASC seeded FPEG Scaffold. Angiogenesis 2013; 16(4):745-57.

Natesan, S, Zamora, DO, Wrice, NL, Baer, DG, Christy, RJ. Bilayer Hydrogel with Autologous Stem Cells Derived From Debrided Human Burn Skin for Improved Skin Regeneration. Journal of Burn Care and Research 2013; 34(1):18-30.

Friedrich, EE, Sun, LT, Natesan, S, Zamora, DO, Christy, RJ, Washburn, NR. Effects of Hyaluronic Acid Conjugation on Anti-TNF-α Inhibition of Inflammation in Burns. Journal of Biomedical Materials Research-A 2014 102(5):1527-36

Griffith, GL, Russell, RA, Kasus-Jacobi, A, Thavathiru, E, Gonzalez, ML. CAP37 Activation of PKC Promotes Human Corneal Epithelial Cell Chemotaxis. Investigative Ophthalmology and Visual Science. 2013; 54(10), 6712-6723.

Cheng, X, Poenitzsch, V, Cornell, L, Tsao, C, Potter, T. Electrochemical Bioencapsulation of Nanomaterials Into Collagen for Biomedical Applications. Journal of Encapsulation and Adsorption Sciences. 2013; 3(1):16-23.

Poenitzsch, VZ, Bredbenner, TL, Hornsby, PJ, Cornell, L, Cheng, XG. Electrochemically Directed Assembly of Carbon Nanotubes (CNTs) and Collagen Macromolecules into Macroscopic Hybrid Fibers. Open Journal of Advanced Materials Research 2013; 1(1)7-12.

Klassen, H.; Tucker, B.A.; Liew, C.G.; Ia Cour, M and Wang, H.-C. Stem cells in large animal models of retinal and neurological disease. Stem Cells Int. 2012:460504. 2012.

Whitney Greene, Alberto Muniz, Mark Plamper, Ramesh Kaini, Heuy-Ching Wang, MicroRNA Expression Profiles of Human iPS cells, Retinal Pigment Epithelium derived from iPS, and Fetal Retinal Pigment Epithelium, Journal of Visualized Experiments, 2014, in press

Wang, H.-C., Choi, J.H., Greene, W. A, Plamper, M. L., Cortez, H. E., Chavko, M., Li, Y., Dalle Lucca, J. J., Jae-Hyek Choi, Whitney A. Greene, Mark L. Plamper, Hector E. Cortez, Mikulas Chavko, Yansong Li, Jurandir J. Dalle Lucca, Johnson, A. J. Pathophysiology of Blast-Induced Ocular Trauma with Apoptosis in the Retina and Optic Nerve. Military Medicine, 2014 in press